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Curiosity is the essence of the scientific mind. For example, you know how milk comes out your nose if you laugh while drinking? Well, I'm going to see what happens when I inhale milk INTO my nose and laugh! Idiocy is the essence of the male mind. I'm guessing it will shoot out my ears. Don't you want to see??
Calvin tells Susie that curiosity is the essence of the scientific mind. He asks Susie if she knows how milk comes out your nose when you laugh while drinking. He puts straws into his nostrils and says he's going to see what happens when he inhales milk into his nose, then laughs. Susie says idiocy is the essence of the male mind.